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PNF Preventive Nutrition and Food Science

Open Access


ISSN 2287-8602
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Original

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Original

Prev Nutr Food Sci 2021; 26(3): 321-329

Published online September 30, 2021 https://doi.org/10.3746/pnf.2021.26.3.321

Copyright © The Korean Society of Food Science and Nutrition.

Effect of Lactic Acid Strains Isolated from Kimchi on Atopic Dermatitis and Immunomodulation in NC/Nga Mice

Dakyung Kim1 , Soo-Jeung Park1 , Jinkyung Kim2 , Unpyo Hong3 , and Jeongmin Lee1,2

1Department of Medical Nutrition, Kyung Hee University, Gyeonggi 17104, Korea
2Research Institute of Medical Nutrition, Kyung Hee University, Seoul 02447, Korea
3Rainbowbiotech Inc., Chuncheon 24232, Korea

Correspondence to:Jeongmin Lee, Tel: +82-31-201-3838, E-mail: jlee2007@khu.ac.kr

Received: May 12, 2021; Revised: June 23, 2021; Accepted: June 28, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Kimchi is a traditional Korean food, of which its constituent lactic acid bacteria have been reported to possess various physiological activities. However, few studies have investigated the immunological activity of these bacteria or their effect on atopic dermatitis (AD). We investigated whether a mixture of 6 types of lactic acid bacteria strains (LBS) isolated from kimchi has an immunomodulating effect on atopy. Mice with atopic dermatitis were orally administered LSB from kimchi for 8 weeks, and skin moisture content, scratching behavior, T-and B-cell proliferation, Th1/2 cytokines, and serum IgE and histamine levels were measured. In addition, hematoxylin and eosin and toluidine blue staining were conducted. Mice receiving LBS from kimchi had increased skin moisture content (164.3%) and T-cell proliferation (more than 4-fold), and decreased number of scratching behaviors (78.2%) and B-cell proliferation (63.7%) compared with the 2,4-dinitrochlorobenzene control group. In addition, LBS increased Th1 type cytokines, decreased Th2 type and pro-inflammatory cytokines, and decreased blood IgE (70.4%), histamine (67.6%) and mast cell levels. Therefore, it suggests that LBS of kimchi may be helpful in improving AD caused by immunological imbalance.

Keywords: atopic dermatitis, immunomodulation, kimchi, lactic acid bacteria, Th1/Th2 balance