전체메뉴
Article Search

PNF Preventive Nutrition and Food Science

Open Access


ISSN 2287-8602
QR Code QR Code

Original

Article

Original

Prev Nutr Food Sci 2021; 26(3): 307-314

Published online September 30, 2021 https://doi.org/10.3746/pnf.2021.26.3.307

Copyright © The Korean Society of Food Science and Nutrition.

Effects of Sargassum horneri and Ulva australis Extracts on Body Weight and Serum Glucose Levels of Sprague-Dawley Rats

Young-Hyeon Lee1 , Min-Ho Yeo1 , Seon-A Yoon2 , Ho-Bong Hyun2 , Young-Min Ham2 , Yong-Hwan Jung2 , and Kyung-Soo Chang1

1Department of Clinical Laboratory Science, Catholic University of Pusan, Busan 46252, Korea
2Biodiversity Research Institute, Jeju Technopark, Jeju 63608, Korea

Correspondence to:Kyung-Soo Chang, Tel: +82-51-510-0565, E-mail: kschang@cup.ac.kr

Received: July 7, 2021; Revised: August 11, 2021; Accepted: August 12, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study investigated the safety and functionality of a functional additive for humans and animals from Sargassum horneri (SH) and Ulva australis (UA) waste for recycling marine refuse generated in large quantities in Jeju. Sprague-Dawley rats were orally administered functional additives at 2,000 mg/kg to assess 14-day repeated dose toxicity of the two extracts. For female rats, weight gain after administration of SH was 66.2±18.8% vs. controls. Male rats administered UA showed weight gain of 92.3±8.0% vs. controls. SH and UA significantly decreased serum glucose levels in male rats compared with controls (79.8±11.10% and 76.1±9.67%, respectively). Similarly, significant decrease in serum glucose levels were shown for female rats after administration of SH and UA (79.2±1.58% and 82.8±3.21%, respectively). Furthermore, rats showed significant differences vs. controls in several serological parameters after receiving extracts, however results remained within the normal range. Thus, the SH and UA extracts were considered safe substances that may be used as functional additives to help reduce body weight and serum glucose.

Keywords: functional natural additive, Sargassum horneri, safety evaluation, serum glucose, Ulva australis