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PNF Preventive Nutrition and Food Science

Open Access


ISSN 2287-8602
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Original

Article

Original

Prev Nutr Food Sci 2021; 26(3): 275-284

Published online September 30, 2021 https://doi.org/10.3746/pnf.2021.26.3.275

Copyright © The Korean Society of Food Science and Nutrition.

Hair Growth-Promoting Mechanisms of Red Ginseng Extract through Stimulating Dermal Papilla Cell Proliferation and Enhancing Skin Health

Van-Long Truong and Woo-Sik Jeong

Food and Bio-industry Research Institute, School of Food Science & Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Korea

Correspondence to:Woo-Sik Jeong, Tel: +82-53-950-5775, E-mail: wsjeong@knu.ac.kr

Received: April 20, 2021; Revised: May 21, 2021; Accepted: May 30, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study aimed to investigate the underlying mechanisms of red ginseng extract (RGE) on regulating hair growth and hair follicle development. Results from in vitro studies showed that RGE treatment simultaneously enhanced viability and inhibited apoptosis in human hair dermal papilla cells. Moreover, RGE administration promoted telogen-to-anagen transition, prolonged anagen in hair follicular cycling, and increased the size of hair follicles and skin thickness in a C57BL/6 mouse model. Furthermore, RGE treatment significantly upregulated the expression of β-catenin, phospho-glycogen synthase kinase 3β, cyclin D1, cyclin E, and Bcl-2, phospho-extracellular signal-regulated protein kinase, and phospho-Akt, which are associated with promoting hair growth. In addition, RGE enhanced skin health by activation of antioxidant defense systems. Our data demonstrates that hair regenerative mechanisms of RGE may be mediated by stimulating dermal papilla cell proliferation and enhancing skin functions.

Keywords: alopecia, β-catenin, dermal papilla cell, hair growth, red ginseng extract