Fig. 6. Heatmap representing the binding energies (kcal/mol) between the key active alkaloids of Coscinium fenestratum alkaloid and the top 10 hub genes. Light to dark blue indicates high to small values of the binding energy according to the AutoDock Vina scores, respectively. HIF1A, hypoxia-inducible factor 1; ICAM1, intercellular adhesion molecule 1; SELE, selectin E; MMP, matrix metallopeptidase; KDR, kinase insert domain receptor; FLT1, fms-related receptor tyrosine kinase 1;
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