Table. 2.
Table. 2.
Constipation-related disease: characteristics of selected clinical trials included in the review
| Reference | Type of study | Clinical setting/population | Sample size | Age | Daily dose | Probiotic species | Duration of intervention | System | Main outcomes |
|---|---|---|---|---|---|---|---|---|---|
| Olgac et al., 2020 (Turkey) | RCT | Children with FC | 49 | 4-16 years | 1×108 CFU | 4 weeks | KINDLⓇ HRQOL | Positive effect | |
| Kommers et al., 2019 (Brazil) | RCT | Female university students with intestinal constipation | 63 | 20-40 years Int: 27.15±5.52 Plac: 24.38±5.41 |
109 CFU of each one | 45 days | PAC-QoL | Positive effect | |
| Xinias et al., 2018 (Greece) | Non-randomized clinical trial | Infants with FC | 65 | 3-13 weeks Int: 1.4±0.8 Plac: 1.7±0.9 |
Not reported | 1 month | Not reported (parents completed a QoL) | Positive effect | |
| Cudmore et al., 2017 (Ireland) | RCT | Chronic, FC | 69 | 18-80 years | 6×108 CFU twice daily | Also psyllium and inulin |
4 weeks | PAC-QoL | Positive effect |
RCT, randomized control trial; FC, functional constipation; CFU, colony forming unit; QoL, quality of life; KINDLⓇ HRQOL, KINDLⓇ Health-Related QoL; PAC-QoL, Patient Assessment of Constipation QoL.
Prev Nutr Food Sci 2024;29:237~255 https://doi.org/10.3746/pnf.2024.29.3.237
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