Summary of key findings on the basis of Grading of Recommendations Assessment, Development, and Evaluation (GRADE) analysis
Outcome | Study | Participant | Effect estimate | Quality of evidence (GRADE) | |
---|---|---|---|---|---|
CPR | 13 | 661 | 0.2613 (—0.1401, 0.6626) | 0.2021 | ⊕⊕⊕⊝ Moderate |
IL-6 | 5 | 156 | —0.6409 (—1.6139, 0.3321) | 0.0722 | ⊕⊕⊝⊝ Low |
TNF-α | 3 | 121 | —0.4293 (—0.7821, —0.0764) | 0.0171 | ⊕⊕⊝⊝ Low |
1)Downgraded because of risk of bias (inconsistencies that may affect the quality of evidence).
2)Reduced in value because of imprecision and insufficient precision (less than 400 individuals).
CRP, C-reactive protein; IL-6, interleukin-6; TNF-α, tumor necrosis factor-α.