Fig. 1. Effect of harmine hydrochloride (HMH) on the growth of SK-Hep1 cells. (A) Chemical structure of HMH. (B) Cell survival curve according to HMH treatment: after culturing with 0, 1, 10, 100, and 1,000 μM of HMH for 24, 48, and 72 h, cell viability was measured using an MTT assay. (C) Morphological changes: HMH inhibited the growth of SK-Hep1 cells and reduced their density by inhibiting cell growth in a dose-dependent manner. The results are presented as the mean±SD. Student’s t-test was used to analyze statistical differences between groups (*P<0.05, **P<0.01, ***P<0.001 with respect to the control group). Cell morphology was visualized using an inverted microscope at 200× magnification. Scale bar, 50 μm.

Prev Nutr Food Sci 2023;28:436~443 https://doi.org/10.3746/pnf.2023.28.4.436