Fig. 4. Schematic of genetic engineering of genes in lactic acid bacteria to develop folate overproducers, based on previous studies. The blue arrows indicate that the gene overexpression technique increased folate productivity, whereas the red arrows indicate no increase. Blue circles represent gene repression and blue crossed circles represent gene deletion; both indicate an increase in folate productivity. GTP, guanosine triphosphate; DHPPP, 6-hydroxymethyl-7,8-dihydropterin pyrophosphate; PABA, para-aminobenzoic acid; DHP, dihydropteroate; DHF, dihydrofolate; THF (mono), tetrahydrofolate-monoglutamate; THF (poly), tetrahydro-folate-polyglutamate.
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