Effect of different extracts of
Group | SOD (U/mg protein) | GPx (mM/mg protein) | TBARS (nmol/mg protein) | |||||
---|---|---|---|---|---|---|---|---|
Pancreas | Brain | Pancreas | Brain | Pancreas | Brain | |||
Normal control | 3.51±0.38 |
4.51±0.37 |
64.50±2.42 |
64.53±3.93 |
0.56±0.18 |
0.46±0.25 |
||
Negative control | 1.13±0.25 | 1.03±0.18 | 39.50±2.94 | 38.83±3.76 | 2.40±0.30 | 2.66±0.28 | ||
DM+metformin (200 mg/kg) | 3.26±0.38 |
3.93±0.31 |
62.33±3.66 |
60.00±2.52 |
1.16±0.38 |
1.08±0.18 |
||
DM+PEE (100 mg/kg) | 1.65±0.56 | 1.80±0.58 |
40.16±3.31 | 40.66±5.00 | 2.02±0.11 | 2.09±0.18 |
||
DM+PEE (200 mg/kg) | 2.18±0.53 |
2.08±0.22 |
46.83±5.54 |
44.00±3.79 | 1.96±0.10 |
1.88±0.30 |
||
DM+PEE (400 mg/kg) | 2.46±0.58 |
2.95±0.10 |
56.83±5.38 |
53.16±3.31 |
1.45±0.36 |
1.72±0.22 |
||
DM+EE (100 mg/kg) | 2.13±0.20 |
2.46±0.41 |
43.83±3.40 | 45.66±5.20 | 1.93±0.15 |
1.81±0.33 |
||
DM+EE (200 mg/kg) | 2.13±0.20 |
2.73±0.36 |
50.66±4.96 |
50.66±5.39 |
1.45±0.15 |
1.76±0.15 |
||
DM+EE (400 mg/kg) | 3.15±0.28 |
3.60±0.35 |
60.16±2.22 |
58.33±3.44 |
1.19±0.30 |
1.05±0.24 |
||
DM+AE (100 mg/kg) | 1.88±0.54 |
2.18±0.23 |
41.50±4.76 | 42.50±4.08 | 1.99±0.11 | 1.89±0.30 |
||
DM+AE (200 mg/kg) | 2.06±0.39 |
2.33±0.42 |
49.50±6.89 |
51.50±6.50 |
1.61±0.33 |
1.76±0.12 |
||
DM+AE (400 mg/kg) | 2.83±0.49 |
3.33±0.42 |
58.66±3.20 |
57.16±4.40 |
1.3±0.35 |
1.13±0.30 |
The values are presented as mean±SD for each group (n=8).
Statistical analysis of data was performed using one-way ANOVA followed by Tukey’s multiple range test.
*
SOD, superoxide dismutase; GPx, glutathione peroxidase; TBARS, thiobarbituric acid reactive substance; DM, type 2 diabetes mellitus; PEE, petroleum ether extract; EE, ethanol extract; AE, aqueous extract.