Table. 3.

Table. 3.

Hematological parameters of SD rats treated orally with galacto-oligosaccharide (GOS), assessed in acute and subacute toxicity tests

Hematological parameters Acute toxicity Subacute toxicity


Control GOS Control GOS
Female
RBC (×106/µL) 8.67±0.27 8.44±0.44 7.65±0.50 8.31±0.48
WBC (×103/µL) 3.62±0.27 3.53±1.14 3.07±0.78 4.60±1.96
Hct (%) 53.60±0.42 50.55±1.41 47.73±2.11 50.68±4.14
Hgb (g/dL) 17.20±0.57 15.85±0.60 14.57±0.86 15.92±1.06
MCV (fL) 61.80±1.41 59.95±2.39 62.47±1.69 60.92±1.84
MCH (pg) 19.85±1.20 18.75±0.74 19.03±0.21 19.18±0.30
MCHC (g/dL) 32.10±1.27 31.28±0.32 30.47±0.57 31.46±0.75
Platelets (×103/µL) 959.00±73.54 970.00±195.09 959.00±182.76 937.80±468.08
Male
RBC (×106/µL) 8.61±1.07 7.70±0.12 8.14±0.37 8.29±0.23
WBC (×103/µL) 7.50±0.98 7.19±5.41 4.51±1.37 4.27±0.88
Hct (%) 59.60±8.45 51.23±2.46 54.15±2.05 54.90±0.85
Hgb (g/dL) 17.43±2.12 15.13±0.61 16.25±0.62 16.25±0.35
MCV (fL) 69.15±1.35 66.57±2.21 66.55±0.54 66.30±2.83
MCH (pg) 20.25±0.33 19.60±0.50 19.98±0.17 19.55±0.92
MCHC (g/dL) 29.28±0.76 29.50±0.26 30.00±0.24 29.55±0.21
Platelets (×103/µL) 1,290.33±247.84 1,049.33±245.40 1,116.00±96.61 1,235.00±94.04

Values are mean±SD for 5 rats/group.

The differences between the control and treated groups were evaluated by Student’s t-tests.

Group for acute toxicity was given water vehicle or GOS at 5,000 mg/kg once followed by no treatment for 14 days. Group for subacute toxicity was given water vehicle or GOS at 1,000 mg/kg daily for 28 days.

Prev Nutr Food Sci 2021;26:315~320 https://doi.org/10.3746/pnf.2021.26.3.315
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