Table. 4. Table 4

Blood biochemical parameters of Sprague Dawley rats treated orally with DNF-10 for the evaluation of acute and subacute toxicity

Blood biological parameters	Acute toxicity		Subacute toxicity

	Control	DNF-10	Control	DNF-10
Female
ALB (g/dL)	4.61±0.10^ns	4.47±0.10	5.27±0.09^ns	5.54±0.12
ALT (U/L)	31.00±1.18^ns	32.78±1.93	33.00±4.80^ns	35.22±4.44
AST (U/L)	76.56±2.66^ns	73.78±2.64	86.11±15.82^ns	80.22±14.83
BIL (mg/dL)	0.49±0.03	0.38±0.03*	0.42±0.02^ns	0.36±0.03
BUN (mg/dL)	17.43±0.83^ns	16.79±0.92	17.03±0.82^ns	17.38±0.72
CPK (U/L)	165.44±32.11^ns	136.89±15.33	63.00±2.45^ns	54.89±2.99
CRE (mg/dL)	0.36±0.02^ns	0.38±0.02	0.46±0.03	0.35±0.02**
GLU (mg/dL)	134.44±12.98^ns	162.56±21.63	211.22±15.13^ns	225.89±10.36
HDL (mg/dL)	54.67±4.00^ns	60.89±3.19	61.00±3.47^ns	58.00±3.00
LDH (U/L)	235.00±20.24^ns	236.78±36.17	175.00±8.85^ns	157.22±19.69
NH₃ (μg/dL)	428.89±54.57^ns	479.56±32.67	355.44±28.35^ns	342.00±25.59
TCHO (mg/dL)	80.33±6.78^ns	84.11±5.94	143.78±8.70^ns	146.44±5.44
TP (g/dL)	6.33±0.10^ns	6.12±0.07	7.38±0.14^ns	7.56±0.14
TG (mg/dL)	43.44±3.46^ns	47.44±5.20	82.11±11.79^ns	66.11±7.89
UA (mg/dL)	3.78±0.23^ns	4.32±0.17	4.53±0.29^ns	4.70±0.24
Male
ALB (g/dL)	4.40±0.06^ns	4.38±0.08	4.28±0.08	4.53±0.06*
ALT (U/L)	47.89±2.49	40.56±0.75*	29.78±1.41^ns	33.78±1.09
AST (U/L)	74.89±2.81^ns	72.00±2.16	63.67±4.64^ns	77.78±5.08
BIL (mg/dL)	0.34±0.03^ns	0.30±0.02	0.26±0.20^ns	0.20±0.02
BUN (mg/dL)	18.16±0.77^ns	17.96±0.59	19.90±1.42^ns	17.61±1.12
CPK (U/L)	103.67±8.68^ns	108.89±10.65	82.33±20.35^ns	139.33±17.89
CRE (mg/dL)	0.36±0.02^ns	0.34±0.03	0.36±0.02^ns	0.32±0.01
GLU (mg/dL)	220.44±20.77^ns	237.67±26.44	374.67±25.03^ns	327.22±23.66
HDL (mg/dL)	52.67±1.87^ns	47.67±2.15	75.44±3.59^ns	78.78±2.80
LDH (U/L)	154.67±19.47^ns	141.56±15.47	183.86±38.47^ns	195.60±12.39
NH₃ (μg/dL)	462.89±35.52^ns	463.11±28.99	381.67±23.50^ns	335.89±35.58
TCHO (mg/dL)	87.33±2.92^ns	80.67±2.50	104.89±6.20^ns	105.33±6.74
TP (g/dL)	6.22±0.08^ns	6.16±0.09	6.43±0.09^ns	6.33±0.53
TG (mg/dL)	58.89±4.71^ns	60.11±1.90	55.33±5.07^ns	54.11±3.39
UA (mg/dL)	5.34±0.28^ns	5.32±0.17	6.90±0.53^ns	6.20±0.63

Values are mean±SEM for each group.

Significant differences at *P<0.05 and **P<0.01, respectively by Student’s t-test.

All abbreviations in Table 4 are described in MATERIALS AND METHODS.

^nsNot significant.

Prev Nutr Food Sci 2021;26:75~81 https://doi.org/10.3746/pnf.2021.26.1.75