Table. 2.

Table. 2. Table 2

Organ weights of Sprague-Dawley rats treated orally with DNF-10 for the evaluation of acute and subacute toxicity (unit: g/100 g of body weight)

Organ	Acute toxicity			Subacute toxicity

	Control	DNF-10		Control	DNF-10
Female
Liver	3.42±0.08^ns	3.58±0.09		2.57±0.05	2.78±0.07*
Kidney	0.86±0.02^ns	0.86±0.02		0.60±0.02	0.67±0.02*
Spleen	0.21±0.01^ns	0.22±0.01		0.15±0.01^ns	0.16±0.01
Heart	0.41±0.01^ns	0.44±0.01		0.31±0.01^ns	0.33±0.04
Lung	0.63±0.04^ns	0.62±0.03		0.46±0.02^ns	0.53±0.03
Brain	0.81±0.03^ns	0.84±0.02		0.60±0.02^ns	0.62±0.02
Thyroid	0.24±0.02^ns	0.25±0.02		0.16±0.01^ns	0.17±0.01
Ovary	0.06±0.00^ns	0.06±0.00		0.04±0.00^ns	0.04±0.00
Uterus	0.21±0.01^ns	0.20±0.01		0.18±0.03^ns	0.22±0.02
Male
Liver	3.54±0.07^ns	3.52±0.12		2.64±0.06^ns	2.78±0.13
Kidney	0.89±0.22^ns	0.91±0.02		0.68±0.03^ns	0.69±0.02
Spleen	0.21±0.11^ns	0.21±0.01		0.15±0.01^ns	0.15±0.01
Heart	0.42±0.01^ns	0.42±0.02		0.32±0.01^ns	0.31±0.01
Lung	0.57±0.04^ns	0.54±0.04		0.37±0.01^ns	0.41±0.02
Brain	0.62±0.01^ns	0.61±0.01		0.35±0.01	0.39±0.01**
Thyroid	0.18±0.01^ns	0.20±0.01		0.14±0.02^ns	0.14±0.01
Testis	0.95±0.03^ns	0.96±0.03		0.63±0.02^ns	0.65±0.04
Epididymis	0.13±0.01^ns	0.15±0.01		0.14±0.01^ns	0.16±0.01

Values are mean±SEM for each group.

Significant differences at *P<0.05 and **P<0.01, respectively by Student’s t-test.

^nsNot significant.

Prev Nutr Food Sci 2021;26:75~81 https://doi.org/10.3746/pnf.2021.26.1.75

© Prev. Nutr. Food Sci.