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Preventive Nutrition and Food Science
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Preventive Nutrition and Food Science 2017 Jun; 22(2): 90-99

Differential Effects of Cod Proteins and Tuna Proteins on Serumand Liver Lipid Profiles in Rats Fed Non-Cholesterol- and Cholesterol-Containing Diets

Ryota Hosomi1, Hayato Maeda2, Yuki Ikeda1, Yuko Toda1, Munehiro Yoshida1, and Kenji Fukunaga1
1Laboratory of Food and Nutritional Sciences, Faculty of Chemistry, Materials, and Bioengineering, Kansai University, Osaka 564-8680, Japan 2Laboratory of Food Chemistry, Faculty of Agriculture and Life Science, Hirosaki University, Aomori 036-8561, Japan
ABSTRACT: Fish muscles are classified into white and red muscles, and the chemical composition of the two fish muscles have many differences. Few reports have assessed the health-promoting functions of white fish muscle proteins (WFP) and red fish muscle proteins (RFP). We therefore evaluated the mechanisms underlying the alteration of lipid profiles and cholesterol metabolism following the intake of WFP prepared from cod and RFP prepared from light muscles of tuna.Male Wistar rats were divided into six dietary groups: casein (23%), WFP (23%), and RFP (23%), with or without 0.5% cholesterol and 0.1% sodium cholate. Compared to the WFP-containing diet, the RFP-containing diet supplemented with cholesterol and sodium cholate significantly increased serum and liver cholesterol contents. However, in the RFP groups, an alteration in cholesterol metabolism including an increased tendency to excrete fecal sterols and hepatic cholesterol 7α-hydroxylase was related to the reduction of hepatic cholesterol contents. This phenomenon might be related to the tendency of an increased food intake in RFP-containing diets. These results highlight the differential effects of WFP and RFP on serum and liver lipid profiles of Wistar rats fed non-cholesterol- or cholesterol-containing diets under no fasting condition.
cod protein, tuna protein, lipid metabolism, cholesterol, rat
Prev Nutr Food Sci 2017 Jun; 22(2): 90-99
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